Watch Out, Eli Lilly and Novo Nordisk: Viking Therapeutics Just Started Testing a Weight Loss Drug That Goes Beyond GLP-1

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The human appetite has more than one off switch, and drugmakers like Eli Lilly ( LLY +0.76% ) and Novo Nordisk ( NVO 2.31% ) are doing their darndest to identify and develop a medicine to target every single one. On June 24, Viking Therapeutics ( VKTX +1.95% ) announced a phase 1 trial for one of its candidates that's attempting to flip one of those as-yet unmedicated appetite switches. That marks its first obesity candidate working outside the incretin pathway that includes GLP-1, or glucagon-like peptide-1, the hormone behind Ozempic and Wegovy and one of two hormones behind Zepbound and Mounjaro. Let's take a look at this program and determine whether it's really going to be a threat to Novo Nordisk and Eli Lilly. Amylin is a hormone produced in the pancreas that is released with insulin after a meal, activating receptors in the brain stem that promote the feeling of fullness, and also slowing stomach emptying. That pathway is adjacent to the one that the GLP-1 medicines use, so it could technically be targeted by a combination therapy affecting both.

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Viking Therapeutics (VKTX) has initiated Phase 1 clinical trials for a new obesity drug candidate beyond existing GLP-1 classes. By targeting the amylin hormone pathway to induce satiety, it challenges the market dominance of Eli Lilly and Novo Nordisk. Investors should monitor future clinical data for potential reshuffling of the obesity treatment market landscape.

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Viking Therapeutics (VKTX) has launched Phase 1 clinical trials for a new obesity drug candidate, distinct from the traditional GLP-1 class. By targeting the amylin hormone pathway to induce satiety, the company is challenging the monopoly held by industry giants Eli Lilly and Novo Nordisk. Investors need to closely watch upcoming clinical results, as they could fundamentally reshape competition in the obesity treatment sector.

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